It is also stable in harsh conditions like stomach acid, a rare trait for peptide drugs
The resulting bioavailability of oral semaglutide is approximately 1% meaning for every 14 mg tablet of oral Wegovy, roughly 0.14 mg reaches systemic circulation
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For example, semaglutide 2.4 mg showed a mean change of -14.9% at 68 weeks vs -2.4% with placebo in one major trial