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When -tocopherol (-TOH) neutralizes a free radical, such as a lipid peroxyl radical (LOO), it becomes oxidized itself, forming -TO, which can in turn promote the oxidation of lipoproteins under certain conditions in the test tube, thus propagating a chain reaction

The time-to-event model also suggested that fasting glucose, systolic blood pressure, total cholesterol and triglycerides would return to baseline levels within a year of drug cessation, while HbA 1c and diastolic blood pressure were predicted to return to baseline by 1.4 years

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