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The SURMOUNT-5 trial, published in The New England Journal of Medicine in May 2025, is the first large randomized study to compare tirzepatide and semaglutide directly in adults with obesity

Eur Stroke J

Similarly, the LEADER trial with liraglutide showed a numerically higher, though non-significant, rate of diabetic retinopathy events compared to placebo (HR, 1.15

But heres the problem: GLP-1s dont address the root causes that led to insulin resistance, inflammation, and hormone imbalance in the first place

Ever since these medications came out, people have been jumping on the bandwagon, selling berberine supplements, and calling it something else, Dr

PlexusDx delivers prescription-strength semaglutide from licensed 503A compounding pharmacies, allowing your provider to customize your dosing schedule to match your tolerance level