If you're also taking an SGLT2 inhibitor, this medication is more likely responsible
PTD-DBM is a synthetic peptide consisting of a protein transduction domain (for cell membrane penetration) fused to a Dishevelled binding motif (for targeting the CXXC5-Dishevelled interaction)
Published binding assays show PT-141's Ki for MC4R is approximately 0.9 nM, compared to 12 nM for MC1R, meaning it activates sexual arousal pathways at doses far below the threshold for melanogenesis
Significantly reduced plasma insulin levels compared to the high-selenium alone group
Markopoulos MC, Valsamakis G, Kouskouni E, Boutsiadis A, Papassotiriou I, Creatsas G, Mastorakos G
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