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Preservation of lean mass during weight reduction is crucial, as skeletal muscle is a primary determinant of basal metabolic rate and glucose disposal

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Muscles and tendons are excessively irritated by various painful stimuli in people with fibromyalgia

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In addition to inducing HF by promoting atherosclerotic progression, elevated plasma TMAO levels may accelerate myocardial hypertrophy, exacerbate mitochondrial dysfunction, and induce transverse-tubule (T-tubule) remodeling in cardiomyocytes (93)