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The formulation of exenatide ER comprises the encapsulation of exenatide IR peptides within 0.06 mm-diameter injectable microspheres made of poly-(D,L lactide-co-glycolide) a biodegradable medical polymer enabling controlled, gradual drug release over an extended period (89)

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The increased expression of numerous cell adhesion molecules accelerates the adherence to the endothelium of pro-inflammatory leukocytes which in turn contributes to the development of atherosclerosis

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Retrograde Mitochondrial-Nuclear Signaling One interesting feature of MOTS-c biology is that MOTS-c seems to travel to the nucleus of cells under conditions of stress and alter the expression of nuclear genes that control antioxidant defences as well as metabolic programs