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Gloy VL, Briel M, Bhatt DL, Kashyap SR, Schauer PR, Mingrone G, et al

Although NAD + is utilized as a cofactor or substrate by numerous enzymes to regulate redox status and cellular energy metabolism [36], sirtuins (SIRTs), which are NAD + -dependent deacetylases, play essential roles in cellular biological processes to maintain metabolic homeostasis [35,37,38,39]

This does not mean the medication is no longer active

doi: 10.1023/A:1026299318315 74 AnisimovVNBersteinLMPopovichIGZabezhinskiMAEgorminPAPiskunovaTSet al