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This metabolic sensing function extends to regulation of key metabolic enzymes such as pyruvate dehydrogenase kinase, which is inhibited by low NAD+/NADH ratios, and lactate dehydrogenase, which is activated by high NADH levels, demonstrating the sophisticated regulatory networks that depend on NAD+ redox status

doi: 10.1253/circj.CJ-14-0471 172 MonkJMLiddleDMDe BoerAABrownMJPowerKAMaDWet al

However, the quality of AI-generated insights greatly depends on the quality of data available

Proceedings of the National Academy of Sciences , 83(13), 49044907