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In the current study, ARA 290 significantly improved the total score compared with the placebo group

Magnetic resonance spectroscopy provides complementary biochemical evidence of METH-induced neurotoxicity

Semaglutide attenuates anxious and depressive-like behaviors and reverses the cognitive impairment in a type 2 diabetes mellitus mouse model via the microbiota-gut-brain axis

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Without direct tissue quantification, it is unknown if the CNS exposure was high, or if the large systemic dose simply compensated for low anatomical delivery efficiency across the nasal mucosa