S., Raspini, B., Pivari, F., Dogliotti, E., & Cena, H
In the SURMOUNT-5 triala head-to-head, open-label, randomized controlled studytirzepatide (Zepbound) was compared to semaglutide (Wegovy) in adults with obesity or overweight and at least one comorbidity (e.g., hypertension, dyslipidemia, obstructive sleep apnea, or cardiovascular disease), but without type 2 diabetes.(11) At maximum tolerated doses over 72 weeks, Zepbound resulted in a mean weight reduction of 20.3%, compared to 13.2% with Wegovy.(11) Patients on the highest dose of tirzepatide and semaglutide reported nausea (31%, 14.4%) and diarrhea (23%, 14%).(9) Tirzepatide is currently the only FDA-approved pharmacotherapy to achieve this level of weight loss
Aids in fatty acid metabolism
Zheng Y, Xiao Y, Zhang D, et al
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A systematic review of population pharmacokinetics of valproic acid