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The glucagon receptor component is the critical differentiator: activation drives hepatic fat oxidation, increased energy expenditure, and thermogenesismechanisms absent in dual or single agonists

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Galanin Galanin is a neuropeptide in the central nervous system

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Increased production of ROS and RNS usually result in production of more potent peroxynitrite (ONOO ), which interacts with cellular macromolecules such as DNA, proteins, and lipids to produce oxidized DNA, proteins, and lipid peroxides, respectively [46]