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Since tirzepatide impacts GLP-1 and GIP it produces better results for weight loss

Bauer AJ, Gieschler S, Lemberg KM, McDermott AE, Stockwell BR

An additional mode of communication from the gut to the brain includes the enteric nervous system (ENS) and sensory neurons expressing receptors to TNF-, IL-1 or IL-6 (243), and to 5-HT (244), which is abundantly produced at the gut level (245) (upwards black arrows in Figure 2 )

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Importantly, ALT was not activated in normal cells

Extremely high doses of APAP result in severe liver damage accompanied by dramatically diminished glucuronidation and sulfation capacities [10]