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Acknowledgements The authors sincerely thank all participants involved in this study

Glutathione as an antioxidant Glutathione is an important antioxidant in our body and is found in almost every cell

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Two major lipid peroxidation products, malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), increase with aging and contribute to the pathogenesis of AMD 63,64,65

10.1098/rsob.120144 Open

h , Volcano plots of the fold change in mitochondrial metabolite abundance (log 2 ) versus P values (-log) from HEK-293T SLC25A39 knockout cell line expressing a vector control or SLC25A40 cDNA