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The effects of combining aerobic and heavy resistance training on body composition, muscle hypertrophy, and exercise satisfaction in physically active adults
If nasal delivery achieves effective central appetite suppression at lower total systemic doses than injection, the cost per therapeutic outcome could potentially favor the nasal route despite lower bioavailability
Patients should never administer two doses to 'catch up', as this increases the risk of adverse effects, particularly gastrointestinal symptoms
Eligibility typically requires a BMI 35 kg/m (or 32.5 kg/m in people from certain ethnic groups), or a BMI 30 kg/m with weight-related comorbidities, alongside engagement with lifestyle modification programmes
Their weight loss may slow, plateau or fail to materialize altogether, even with consistent use