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severe comorbid conditions such as advanced cardiovascular disease, chronic kidney disease, or uncontrolled diabetes

Nat Rev Endocrinol 6:279289 Keenan HA, Sun JK, Levine J, Doria A, Aiello LP, Eisenbarth G, Bonner-Weir S, King GL (2010) Residual insulin production and pancreatic -cell turnover after 50 years of diabetes: Joslin Medalist Study

N Engl J Med 373(23):22472257 Muskiet MHA, Tonneijck L, Huang Y, Liu M, Saremi A, Heerspink HJL et al (2018) Lixisenatide and renal outcomes in patients with type 2 diabetes and acute coronary syndrome: an exploratory analysis of the ELIXA randomised, placebo-controlled trial

Dosages can be increased every 30 days until the maximum dose is reached

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This protein carries oxygen in red blood cells