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Because they work through entirely different biological pathways, there is no mechanism conflict between the two therapies

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Topical applications appear generally well-tolerated in small studies, but systemic safety, long-term effects, and drug interactions remain inadequately characterized

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In the key trial supporting its approval for postherpetic neuralgia, somnolence was reported in 21% of patients receiving gabapentin 1,800 mg/day versus 5% on placebo [3]