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Advanced glycation end-products induce vascular endothelial growth factor to upregulate the expression of matrix metalloproteinases, which in turn affect tight junction proteins and P-glycoprotein [39]

DOI: 10.1038/ejcn.2017.132 Honda Y, Kessoku T, Sumida Y, et al

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This reduction is largely due to the disruption of lymphopoiesis, as zinc deficiency leads to a significant decline in pre-B cells [291]

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