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A 2013 study (PMID 23106397) employed DES(1-3) IGF-1 as an IGF1R-activating tool in oral squamous cell carcinoma cells to investigate resistance mechanisms to EGFR tyrosine kinase inhibitors

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Dosage Schedule: The treatment usually starts with an intensive phase (e.g., daily or every other day) to replenish stores, followed by a less frequent maintenance phase (e.g., once a month or once every few months)

For the comprehensive knowledge of external-stimuli viz light, thermal, ultrasound, magnetic field, and electric field responsive systems, and non-cleavable systems viz charge inversion, polarity variation, expansion and shrinking, see the review articles by Deng et al

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