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It often supplements (rather than replaces) other therapies

If we ignore the intestinal versus pancreatic source of GLP-1 topic and just focus on the fact that GLP-1 regulates insulin secretion by acting directly on -cell GLP-1rs and either directly or indirectly suppresses glucagon then under what circumstance is glucagon important for -cell GLP-1r signaling

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Those safeguards exist specifically to prevent dosing errors and to catch adverse reactions early