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This is the most common question and the answer from a mechanistic standpoint is yes, they are complementary rather than redundant : BPC-157 works through nitric oxide and growth factors (gut-mediated) TB-500 works through actin mobilization and cell migration (structural) These are non-overlapping pathways, which is the theoretical basis for combining them

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21: Clinical science 91:575-582, 1996

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It is therefore suggesting that the slight change of relaxation observed in the aorta without endothelium ex vivo might be due to some mechanism unrelated to the direct nitric oxide stimulation which needs further investigation