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Patients with certain GLP1R variants may achieve therapeutic benefit at lower doses, while others require higher exposure for equivalent weight lossand mismatched dosing in either direction increases overdose or inefficacy risk

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Conclusion NPT1, NPT4, ABCG2 expressed on the apical membrane and OAT1, OAT3 expressed on the basolateral membrane have been confirmed to contribute to the secretory transport of urate from proximal tubular epithelial cells into the tubule lumen (Wen et al., 2020)

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