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One last article was eliminated in final analysis because the laboratory methodology and pathogenesis of periodontal disease are now refuted by more recent scientific evidence

Scarpellini E, Arts J, Karamanolis G, Laurenius A, Siquini W, Suzuki H, Ukleja A, Van Beek A, Vanuytsel T, Bor S, Ceppa E, Di Lorenzo C, Emous M, Hammer H, Hellstrm P, Laville M, Lundell L, Masclee A, Ritz P, Tack J

More recent studies have explored GHK-Cu's potential role in epigenetic regulation, with in vitro data suggesting influence over gene expression patterns associated with cellular senescence and antioxidant response elements (Nrf2 pathway)

Fan Y, Ye J, Kang Y, Niu G, Shi J, Yuan X, et al

Nrf2ekeap1 system versus NF-kB: The good and the evil in chronic kidney disease