melanotic bowel movement This is melanosis coli—a result of long-term stimulant laxative use (like Senekot)., ⸻, Have you ever heard of melanosis coli?, It’s not “just staining.” It’s your colon screaming for help., Senekot Melanosis coli: A comprehensive review

The complete absence of dimerization in C396S suggests that Cys396 may be involved in an inter-molecular disulfide bond that results in the formation of an oligomeric structure that combines GSAAT with other enzymes, factors or molecular chaperones involved in ALA formation, such as GluTR, GBP ( The purified UT recombinant GSAAT variants were not entirely reduced, and additional reducing power enhanced their enzyme activities

some are investigational drugs not approved by the FDA

Teubner (2005) Die ganze Welt der Vitamine, Mineralstoffe und Enzyme

10.1016/j.yexcr.2020.111910 157 YuZ.XiaoJ.ChenX.RuanY.ChenY.ZhengX.et al (2022)

The Los Angeles Atherosclerosis Study

Another explanation for NAD + decline with age is the increased NAD + consumption by PARP or CD38