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The integrated crosstalk among these pathways enhances cellular repair, energy homeostasis, and resilience, positioning GLP-1 RAs as central modulators of cellular homeostasis and linking molecular repair programs to translational gains in healthspan

143 By modulating calcium responses to glutamate and membrane depolarization, 144 and AMPA receptors, 139,145 GLP-1 RA may play important roles in regulating neuronal plasticity