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Epitalon treatment significantly decreased frequency of spindle defects and abnormal distribution of cortical granules during aging for 12h and 24h, while increased mitochondrial membrane potential and DNA copy number of mitochondria, thus decreasing apoptosis of oocytes by 24h of in vitro aging

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REDEFINE 1 (Phase 3a, NEJM 2025) Garvey et al., n=3,417, 68 weeks

J., Tan, D

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Together these compounds allow researchers to examine complementary and potentially synergistic multi-pathway signaling dynamics in controlled laboratory models