Glutathione further supports this by protecting the cells of the gut wall from damage
Glutathione can also become depleted by increased exposure to medications, toxins, heavy metals, solvents, pesticides, or alcohol. A high purity form of glutathione The issue with glutathione, as with most endogenous antioxidants, is its molecules are naturally reactive and dont cope well with life on the shelf or the passage through the gastrointestinal tract
Grant, C.M., MacIver, F.H
Product Recommendations $125.00 Fully Bioactive L-Methylfolate & Vitamin B12 Supplement Cofactors Supporting Methylation, Cognition & Wellbeing Superior-Absorbing Magnesium, Proven in Human Study 3rd-Party Tested for Purity & Safety, Non-GMO, Gluten-Free Understanding MTHFR and Its Role in the Body MTHFR stands for Methylenetetrahydrofolate Reductase , which refers both to an enzyme and the gene responsible for its production
So the biological rationale is real and multi-pronged
Oral B12 supplements lose 98-99% of the vitamin during digestion