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F.OakleyF.Correia-MeloC.GreavesL.et al (2014)

While much of our work today focuses on protecting brain health as we age, we also support research and education on childrens brain development through initiatives such as Smart Kids & Teens

Their roles include chromatin modification and transcriptional regulation of nearby genes

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When MTHFR diverts 5,10-MTHF to 5-MTHF production, less 5,10-MTHF is available for TYMS reducing dTMP synthesis and causing the intracellular dUTP/dTTP ratio to shift toward excess dUTP